drugset / Trial / NCT05850832

Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study

NCT05850832

Phase 2/3 Completed 60 enrolled Alexandria University
RandomizedParallel-groupDouble-blindTreatment

Summary

sixty patients, of both sexes, of ASA I or II planned for ambulatory laparoscopic cholecystectomy under general anaesthesia were engaged into 2 groups. Esmolol group were given 1 mg/kg loading dose followed by 30 μg/kg/min throughout the surgery, whereas magnesium sulphate (MgSo4) group were given loading dose 40 mg/kg over 15 mins then maintenance dose 15 mg/kg/h till end of surgery. General anaesthesia was standardized and postoperative analgesia included fentanyl. Variables denoting immediate recovery from anaesthesia, pain score and time of stay in PACU were recorded. White-Song score ≥ 12 along with pain score \< 4 were the cut off levels for patients' discharge from PACU.

Timeline

Start
2022-10-05
Primary completion
2023-01-05
Completion
2023-04-10

Drugs

EvaluationDrugModalityDoseRoute
Comparator Esmolol Other / unclassified 30 ug/kg
Comparator Magnesium Sulfate Other / unclassified 15 mg/kg

Indications

No indication recorded.