Lacosamide Versus Propranolol in Migraine

Summary

Investigators aim to compare the effect of lacosamide versus propranolol in migraine by assessing the absolute reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency compared to the baseline frequency.

Timeline

Start

2022-06-01

Primary completion

2023-07-30

Completion

2023-08-30

Publications

• Background Mushet GR, Miller D, Clements B, Pait G, Gutterman DL. Impact of sumatriptan on workplace productivity, nonwork activities, and health-related quality of life among hospital employees with migraine. Headache. 1996 Mar;36(3):137-43. doi: 10.1046/j.1526-4610.1996.3603137.x.
• Results Lipton RB, Scher AI, Kolodner K, Liberman J, Steiner TJ, Stewart WF. Migraine in the United States: epidemiology and patterns of health care use. Neurology. 2002 Mar 26;58(6):885-94. doi: 10.1212/wnl.58.6.885.
• Results Lipton RB, Liberman JN, Kolodner KB, Bigal ME, Dowson A, Stewart WF. Migraine headache disability and health-related quality-of-life: a population-based case-control study from England. Cephalalgia. 2003 Jul;23(6):441-50. doi: 10.1046/j.1468-2982.2003.00546.x.
• Zeinhom MG, Rezk SG, Mohamed AM, Ahmed SR. Lacosamide Versus Propranolol in Episodic Migraine, a Randomized Controlled Double-blinded Trial. Mol Neurobiol. 2026 Mar 21;63(1):512. doi: 10.1007/s12035-026-05756-5.

Drugs

Indications