drugset / Trial / NCT05853575

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

NCT05853575

Phase 2 Active not recruiting 200 enrolled Mirati Therapeutics Inc.
RandomizedSequentialOpen-labelTreatment

Summary

This study will evaluate the efficacy of two dosing regimens of adagrasib (600 mg BID versus 400 mg BID) in patients with NSCLC with KRAS G12C mutation.

Timeline

Start
2024-02-16
Primary completion
2026-07-30
Completion
2026-07-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Adagrasib Small molecule 400 mg
Subject Adagrasib Small molecule 600 mg