Synaptic Imaging and Network Activity in Treatment Resistant Depression

Summary

The main aim of this research is to explore the effects that ketamine has on the functional connectivity of the brain in participants with treatment resistant depression (TRD). This study will investigate the relationship between these changes and response to treatment as measured by clinical scales, as well as examining drug induced changes in reward and emotion based brain activity, structural connectivity, cerebral blood flow, cognition, metabolism and blood markers of brain plasticity.

Timeline

Start

2021-10-20

Primary completion

2023-09-13

Completion

2023-09-13

Drugs

Indications