Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients

Phase 2 Unknown 60 enrolled Xiaobo Yang, MD

RandomizedParallel-groupSingle-blindTreatment

Summary

The purpose of this study is to evaluate the efficacy and safety of fospropofol disodium for injection compared to propofol for deep sedation in mechanically ventilated ICU patients.

Timeline

Start: 2023-06-01
Primary completion: 2024-03-01
Completion: 2024-06-01

Publications

Gao X, Gao C, Fang X, Ren L, Zhang H, Tang Y, Yuan Y, Qi H, Shu H, Zou X, Yang X, Shang Y. Fospropofol disodium versus Propofol for deep sedation in critically ill patients: a randomized pilot study. BMC Anesthesiol. 2025 Apr 10;25(1):166. doi: 10.1186/s12871-025-03025-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Propofol	Small molecule	3 mg/kg	—
Subject	fospropofol	Small molecule	10 mg/kg	—

Indications

No indication recorded.