drugset / Trial / NCT05872698
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.
Phase 4
Active not recruiting
763 enrolled
King's College Hospital NHS Trust
Brighton and Sussex University Hospitals NHS Trust · collabCardiff University · collabKing's College London · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Research has proven that large varices can be treated with beta-blockers (a type of anti-hypertensive medication) to reduce the pressure in the veins. The management of small varices is still uncertain. This study aims to discover if beta blockers can be used in this setting. We hypothesize that beta blockers will reduce the risk of bleeding from small varices from 20% to 10% over a period of 3 years, resulting in significant cost savings to the NHS from better patient outcomes.
Timeline
- Start
- 2019-04-01
- Primary completion
- 2026-12
- Completion
- 2026-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Carvedilol | Other / unclassified | 6.25 mg | Oral |
| Comparator | Carvedilol | Other / unclassified | 12.5 mg | Oral |