drugset / Trial / NCT05875701

Phase 3 Study of Novavax Vaccine(s) as Booster Dose After mRNA Vaccines

NCT05875701

Phase 3 Completed 147 enrolled Novavax
RandomizedParallel-groupOpen-labelPrevention

Summary

This is an open-label Phase 3 study evaluating the immunogenicity and safety of Novavax vaccine(s) with Matrix-M™ adjuvant (ancestral strain NVX-CoV2373 and an alternative strain and/or multivalent Novavax vaccine) as booster doses following a series of primary and booster doses of authorized/approved mRNA vaccines followed by a single booster dose of NVX-CoV2373 in the Novavax 2019nCoV-307 study (NCT05463068).

Timeline

Start
2023-03-28
Primary completion
2023-11-11
Completion
2023-11-11

Drugs

EvaluationDrugModalityDoseRoute
Subject NVX-CoV2373 Vaccine 5 ug
Subject NVX-CoV2373 Vaccine 50 ug
Subject NVX-CoV2373 Vaccine 0.5 ml
Subject SARS-CoV-2 rS antigen/Matrix-M Adjuvant Unknown 5 ug Intramuscular
Subject SARS-CoV-2 rS antigen/Matrix-M Adjuvant Unknown 50 ug Intramuscular
Subject SARS-CoV-2 rS antigen/Matrix-M Adjuvant Unknown 0.5 ml Intramuscular

Indications