A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy

Summary

This study will assess the safety and efficacy of JZP258 (XYWAV) on sleepiness, polysomnography, and functional outcomes in patients with idiopathic hypersomnia (IH) or narcolepsy.

Timeline

Start

2023-07-27

Primary completion

2025-03-13

Completion

2025-03-13

Publications

• Schneider LD, Ruoff CM, Plante DT, Nichols DA, Steininger TL, Fuller DS, Kirby MT, Akerman S, Alexander JK, Whalen M, Cairns A. Effectiveness and Safety of Low-Sodium Oxybate in Participants with Narcolepsy: Primary Results from the DUET Study. Neurol Ther. 2026 Apr 30. doi: 10.1007/s40120-026-00921-3. Online ahead of print.
• Plante DT, Cairns A, Schneider LD, Nichols DA, Steininger TL, Fuller DS, Kirby MT, Akerman S, Alexander JK, Whalen M, Ruoff CM. Effectiveness and Safety of Low-Sodium Oxybate in Participants with Idiopathic Hypersomnia: Primary Results from the DUET Study. CNS Drugs. 2026 Jun;40(6):803-822. doi: 10.1007/s40263-025-01262-9. Epub 2026 Mar 14.

Drugs

Indications