Dupilumab in Chinese Adult Participants With CRSwNP

Summary

This is a parallel group, Phase 3, 2-arm study for treatment. The purpose of this study is to evaluate dupilumab subcutaneous (SC) injections compared to placebo in Chinese adult participants with CRSwNP, on a background therapy with intranasal corticosteroids (budesonide nasal spray). Study details include: * The study duration will be up to 40 weeks. * The treatment duration will be up to 24 weeks. * The number of visits will be 7.

Timeline

Start

2023-05-16

Primary completion

2024-09-06

Completion

2024-11-28

Publications

• Xian M, Wang M, Zhao C, Wan L, Xu Y, Meng J, Xu R, Song X, Shi L, Yang Y, Jiang Y, Wu Y, Ling B, Li V, Fontenot AP, Robinson LR, Phadke NA, Wang C, Zhang L. Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo-Controlled, Phase III Trial. Allergy. 2026 Jun 16. doi: 10.1111/all.70414. Online ahead of print.

Drugs

Indications