Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis

Summary

Sepsis, a life-threatening syndrome, is often accompanied by tachycardia in spite of adequate volume resuscitation to correct hypovolemia and vasopressor medication to correct hypotension. Recently, relevant studies have shown that sustained tachycardia in sepsis was also related to high mortality, and appropriate control of heart rate could improve prognosis. Ivabradine reduces heart rate directly without a negative inotropic effect through inhibition of the If ionic current，which is absent from the traditional rate control drug (beta-blockers). This is a prospective, multicenter, randomized, open label study designed to compare ivabradine with placebo on the difference of heart rate and haemodynamics in patients with sepsis.

Timeline

Start

2023-06-01

Primary completion

2026-12-31

Completion

2027-05-31

Publications

• Zheng J, Wen D, Pan Z, Chen X, Kong T, Wen Q, Zhou H, Chen W, Zhang Z. Effect of heart rate control with ivabradine on hemodynamic in patients with sepsis: study protocol for a prospective, multicenter, randomized controlled trial. Trials. 2024 Oct 23;25(1):710. doi: 10.1186/s13063-024-08560-5.

Drugs

Indications