Efficacy of Roflumilast in Prevention of Peripheral Neuropathy

Summary

There are several mechanisms concerning pathophysiology of paclitaxel induced peripheral neuropathy. One of the main mechanisms is induction of Schwann cell dedifferentiation by paclitaxel. At the preclinical level, roflumilast potently inhibited paclitaxel-induced dedifferentiation of cultured Schwann cells, yet this positive effect have not been clinically investigated.

Timeline

Start

2023-07

Primary completion

2023-12

Completion

2023-12

Drugs

Indications