drugset
drugset / Trial / NCT05885685

Investigating the Effects of Nabilone on Endocannabinoid Metabolism

NCT05885685 ↗

Phase 4 Completed 10 enrolled Centre for Addiction and Mental Health
NaSingle-groupOpen-labelBasic science

Summary

The purpose of this study is to learn about the effects of a cannabis-like substance, nabilone, on the levels of endocannabinoid enzyme fatty acid amide hydrolase (FAAH) in brain of healthy individuals. Using magnetic resonance imagine (MRI) and positron emission tomography (PET), the main questions we aim to answer are: 1) Does nabilone decrease levels of FAAH in the brain? and 2) Are changes in levels of FAAH associated with clinical response to nabilone? Participants will complete: * An in-person interview (\~4 hours) * Two brain imaging scanning sessions (\~11 hours) * A one week 2 mg titrated dose of nabilone * Virtual check-ins (up to \~1.5 hours)

Timeline

Start
2023-10-31
Primary completion
2025-12-05
Completion
2025-12-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Nabilone Other / unclassified 2 mg Oral

Indications

No indication recorded.