Allopurinol Improves Heart Function in African Americans With Resistant Hypertension

Summary

African American adults in the United States have the highest prevalence rate of high blood pressure (hypertension) and heart failure in the world. African Americans with treatment resistant hypertension have higher levels of the enzyme - xanthine oxidase compared to Caucasians. This trial will test if administration of the xanthine oxidase inhibitor - Allopurinol (commonly used in the treatment of gout), given over a period of 8 weeks, will improve heart function, exercise ability and quality of life in African American Veterans with resistant hypertension.

Timeline

Start

2024-09-30

Primary completion

2026-04-30

Completion

2026-08-31

Drugs

Indications