Relationship Between Efficacy of Lumateperone and Brain Glutamate and Dopamine

Summary

This study will examine the differential relationships between antipsychotic efficacy and changes in dopaminergic and glutamatergic brain metabolism in lumateperone and risperidone treated early psychosis patients. Baseline glutamate and dopamine brain scans, and symptom severity measures will be collected, followed by repeated measures at 6 weeks. Half of the early psychosis patients will be treated with lumateperone, half with risperidone. Healthy control subejcts will also be examined once.

Timeline

Start

2023-05-11

Primary completion

2024-02-28

Completion

2024-02-28

Publications

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Drugs

Indications