Zinc-containing Vaginal Gel and Oral Fluconazole for Vulvovaginal Candidiasis.

Summary

Vaginitis is one of the most common gynecological problems in women. Candida albicans is responsible for more than 85% of vaginal fungal infections and reinfection after standard treatment is quite common. The aim of this study is to compare the effects of a zinc-containing vaginal gel and oral fluconazole on the treatment and recurrence of vulvovaginal candidiasis (VVC). The investigator's hypothesis is that zinc-containing vaginal gel may decrease the rate of reinfection after standard treatment with oral 150 mg fluconazole.

Timeline

Start

2023-06-10

Primary completion

2026-04-20

Completion

2026-04-20

Publications

• Roselletti E, Kozma B, Ratonyi D, Kunkli A, Kozma B, Takacs P, Wilson D. Vaginal PRA1 identifies clinically relevant Candida albicans vaginitis and excludes asymptomatic colonization: an exploratory study. BMC Microbiol. 2026 Jul 17. doi: 10.1186/s12866-026-05405-w. Online ahead of print.

Drugs

Indications