Secondary Prophylaxis of CMV Infection Using Letermovir After HID-HSCT

Summary

To evaluate the efficacy and safety of secondary prophylaxis of CMV reactivation, clinically significant CMV infection with oral letermovir in Chinese haplo-HSCT patients, as well as treatment-related mortality, all-cause mortality and QoL after transplantation. For enrolled patients, Letermovir would be administered at a dose of 480 mg per day (or 240 mg per day in patients taking cyclosporine). The regimen duration of dosing was approximately 120 days or 16 weeks. Or physicians could adjust regimen duration according to the CMV infection risk factors.

Timeline

Start

2023-07-01

Primary completion

2024-12-31

Completion

2024-12-31

Drugs

Indications

No indication recorded.