drugset / Trial / NCT05916391
Gene Therapy for Diabetic Macular Edema
Phase 1
Recruiting
18 enrolled
Frontera Therapeutics
Peking Union Medical College Hospital · collabThe First Affiliated Hospital of Zhengzhou University · collabTianjin Medical University Eye Hospital · collab
Non-randomizedSingle-groupOpen-labelTreatment
Summary
FT-003 is a gene therapy product developed for the treatment of central involvement diabetic macular edema (CI-DME). Diabetic retinopathy is one of the most common microvascular complications of diabetes mellitus, and diabetic macular edema is the main cause of vision loss in patients with diabetic retinopathy. In the latest guidelines, anti-VEGF therapy is preferred for CI-DME. Administration of FT-003 has the potential to treat CI-DME by providing intraocular protein which is durable expressed in therapeutic level. FT-003 is designed to reduce the current treatment burden which often results in undertreatment and vision loss in patients with CI-DME receiving anti-VEGF therapy in clinical practice.
Timeline
- Start
- 2023-05-19
- Primary completion
- 2025-05-01
- Completion
- 2028-05-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | FT-003 | Unknown | — | Other |