drugset / Trial / NCT05922306
Efficacy of NA Combined With PEG-IFN-α2b in the Continuous Versus Pulsed Treatment of Patients With Chronic Hepatitis B
Phase 0
Recruiting
1084 enrolled
Anhui Medical University
Chaohu Hospital of Anhui Medical University · collabThe First Affiliated Hospital of Bengbu Medical University · collabThe First Affiliated Hospital, University of Science and Technology of China · collabThe Second Hospital of Anhui Medical University · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
Previous studies have shown that there are alterations in the number and affinity of interferon receptors during interferon therapy and that such alterations recover to varying degrees some time after the end of treatment. It can be conjectured that the rest period of pulsed therapy facilitates the recovery of type I interferon receptors and thus the next round of IFN therapy compared to a continuous regimen of interferon.
Timeline
- Start
- 2023-07
- Primary completion
- 2027-06
- Completion
- 2027-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | PEGylated recombinant human interferon alpha-2b | Unknown | 180 ug | Subcutaneous |