drugset / Trial / NCT05928689

Behavioral and Pharmacological Reconsolidation Interference in Misophonia

NCT05928689

Phase 0 Completed 141 enrolled Icahn School of Medicine at Mount Sinai
RandomizedParallel-groupTriple-blindOther

Summary

One of the core processes presumably underlying misophonia - a condition characterized by decreased tolerance for specific sounds - is associative learning. Using behavioral, computational, and neural analyses of emotional learning and memory processes to understand the unknown behavioral and neural mechanisms underlying misophonia's associative learning and memory, the study team will evaluate whether interference with the reconsolidation of a reactivated misophonia memory with propranolol can alleviate aversive reaction to misophonia-related cues.

Timeline

Start
2023-06-02
Primary completion
2024-09-30
Completion
2024-09-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Propranolol Small molecule 40 mg

Indications