drugset / Trial / NCT05962229
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
Phase 1
Recruiting
18 enrolled
University of California, San Francisco
National Institute on Drug Abuse (NIDA) · collab
RandomizedCrossoverSingle-blindBasic science
Summary
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
Timeline
- Start
- 2024-12-06
- Primary completion
- 2027-05
- Completion
- 2027-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | (R)-nicotine | Unknown | — | Inhaled |
| Subject | (S)-nicotine | Unknown | — | Inhaled |
| Subject | Racemic nicotine | Unknown | — | Inhaled |