drugset / Trial / NCT05976347

Identifying and Treating Depression in the Orthopaedic Trauma Population

NCT05976347

Phase 4 Recruiting 100 enrolled Wake Forest University Health Sciences
RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?

Timeline

Start
2025-06-25
Primary completion
2027-05
Completion
2027-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Duloxetine Small molecule 30 mg
Subject Fluoxetine Small molecule 20 mg

Indications