drugset / Trial / NCT05976646
Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion
Phase 1/2
Completed
18 enrolled
Virginia Commonwealth University
National Institute on Drug Abuse (NIDA) · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The overall goal of this project is to collect initial human data on the effects of novel compounds on safety (interactions with an opioid drug, e.g., buprenorphine) and early efficacy signals (subjective effects on negative affect, craving, and opioid withdrawal) in OUD subjects currently in MOUD treatment with buprenorphine.
Timeline
- Start
- 2023-09-18
- Primary completion
- 2025-07-09
- Completion
- 2025-07-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupropion | Small molecule | 105 mg | Oral |
| Subject | Dextromethorphan | Unknown | 45 mg | Oral |