drugset / Trial / NCT05976828

IBRX-042 In Participants With HPV-Associated Tumors

NCT05976828

Phase 1 Active not recruiting 12 enrolled ImmunityBio, Inc.
Non-randomizedSequentialOpen-labelTreatment

Summary

The goal of this clinical trial is to determine the maximum tolerated dose and to find out the side effects of a drug called IBRX-042 at different dose levels in patients with recurrent or progressive Human Papillomavirus (HPV) associated tumors. The main questions it aims to answer are: * What is the maximum tolerated dose of IBRX-042? * How well does the study drug treat cancer? * What effects the study drug may have on the human body and cancer? Participants will receive IBRX-042 at one of three dose levels every 3 weeks for a total of 3 injections. Participants will undergo tests, exams, and procedures that are part of standard of care and for study purposes. IBRX-042 will be administered by injection every 3 weeks for a total of 3 injections.

Timeline

Start
2024-06-14
Primary completion
2027-09-02
Completion
2033-08-14

Drugs

EvaluationDrugModalityDoseRoute
Subject IBRX-042 Unknown 5e+10 unknown Other
Subject IBRX-042 Unknown 1e+11 unknown Other
Subject IBRX-042 Unknown 5e+11 unknown Other