Repurposed Drugs in Research for Cancer Clinical Trials- Pitavastatin

Summary

The goal of this Phase 0 trial is to study if pre-operative oral pitavastatin administration reaches the tumour in patients with primary or a recurrent glioblastoma. The main question\[s\] it aims to answer are: * Does pitavastatin reach a cytotoxic concentration in gadolinium-enhanced tumour tissue after oral administration? * Does pitavastatin achieve a concentration that can synergize with temozolomide in the gadolinium non-enhanced area of the tumour? Participants will receive pitavastatin in differing dosages a week before their elective surgery and blood and tumour samples will be collected.

Timeline

Start

2024-01-18

Primary completion

2024-07-19

Completion

2024-07-19

Drugs

Indications