drugset / Trial / NCT05998642

Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma

NCT05998642

Phase 2 Recruiting 30 enrolled Canadian Cancer Trials Group Janssen, LP · collab
NaSingle-groupOpen-labelTreatment

Summary

This study is being done to answer the following question: Can the addition of a new drug to the usual treatment lower the chance of primary central nervous system lymphoma growing or spreading? This study is being done to find out if this approach is better or worse than the usual approach for this type of cancer. The usual approach is defined as the care most people get for Primary Central Nervous System Lymphoma (PCNSL).

Timeline

Start
2024-02-13
Primary completion
2028-05-31
Completion
2028-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Ibrutinib Small molecule Oral
Background Methotrexate Small molecule 3.5 mg/m2 Intravenous
Background Rituximab Monoclonal antibody 375 mg/m2 Intravenous
Background Rituximab Monoclonal antibody 1400 mg Intravenous

Indications