Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers

Phase 1 Completed 40 enrolled Brigham and Women's Hospital

RandomizedParallel-groupOpen-labelBasic science

Summary

Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery. However, some patients experience an increase of pain into the severe range when the nerve block wears off, also known as rebound pain. The investigators are studying if a nerve block (numbing injection) in the arm causes hyperalgesia (increased pain) when the nerve block is wearing off.

Timeline

Start: 2023-09-28
Primary completion: 2024-05-28
Completion: 2024-05-28

Publications

Chen YK, Wilson JM, Collins PW, Gokul SR, Lirk P, Schreiber KL. Evaluation of Postblock Hypersensitivity Using Quantitative Sensory Testing before, during, and after Axillary Brachial Plexus Block Resolution in Healthy Volunteers. Anesthesiology. 2026 Aug 1;145(2):322-332. doi: 10.1097/ALN.0000000000006082. Epub 2026 Jul 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Mepivacaine	Other / unclassified	1.5 %	Other

Indications

No indication recorded.