Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Summary

This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in central diabetes insipidus (cDI) to improve psychological symptoms and socio-emotional functioning. Optionally, patients can present for additional assessments in sub-studies: * fMRI sub-study at day 14 (± 2 days) (one additional visit) * Social-stress sub-study at day 14 (± 2 days) (one additional visit)

Timeline

Start

2024-01-08

Primary completion

2026-10

Completion

2026-10

Publications

• Atila C, Leibnitz S, Nikaj A, Liechti ME, De Quervain D, Christ-Crain M; OxyTUTION Study Group. Oxytocin substitution therapy in patients with AVP deficiency (central diabetes insipidus): study protocol of a double-blind, randomised placebo-controlled trial. BMJ Open. 2026 May 4;16(5):e109940. doi: 10.1136/bmjopen-2025-109940.

Drugs

Indications