Effectiveness of Tofacitinib in Systemic Sclerosis

Phase 2 Unknown 44 enrolled Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Aristopharma Ltd · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to compare efficacy of tofacitinib with cyclophosphamide in skin thickening in early diffuse cutaneous systemic sclerosis .

Timeline

Start: 2023-11
Primary completion: 2024-05
Completion: 2024-05

Publications

Amin Khan N, Islam A, Shahin A, Jamil Abdal S, Haq SA. Efficacy and Safety of Tofacitinib Compared to Cyclophosphamide in Early Diffuse Cutaneous Systemic Sclerosis: A Randomized Controlled Trial. Cureus. 2026 Feb 7;18(2):e103163. doi: 10.7759/cureus.103163. eCollection 2026 Feb.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tofacitinib	Small molecule	5 mg	Oral

Indications

No indication recorded.