drugset / Trial / NCT06045286

High- and Low-dose Radiotherapy Combined With PD-1 Inhibitors for MSS CRLM

NCT06045286

Phase 1 Unknown 30 enrolled Jiangsu Cancer Institute & Hospital
NaSingle-groupOpen-labelTreatment

Summary

This pilot phase I trial aims to investigate the efficacy and safety of high- and low-dose radiotherapy combined with programmed cell death-1 (PD-1) inhibitors in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) that have failed second-line immunotherapy or above.

Timeline

Start
2023-09-20
Primary completion
2024-09-30
Completion
2025-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Zimberelimab Monoclonal antibody