A Clinical Trial of Adsorbed Cell-free DPT Vaccine (5-component) (for People Aged 6 Years and Above)

Summary

Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis, diphtheria is an acute upper respiratory infectious disease caused by Gram-positive Corynebacterium diphtheriae, and tetanus is a highly fatal disease caused by Clostridium tetani infection. Currently, there is no clinical trial registration of Diphtheria, tetanus, and pertussis (DPT) vaccine applicable to ≥6 years of age in China, therefore, the five-component acellular DPT combination vaccine developed by our research has a promising future.

Timeline

Start

2023-12-06

Primary completion

2024-04-13

Completion

2025-09-28

Publications

• Liu X, Wei C, Huang H, Wan J, Li Y, Wang F, Li S, Wang Y, Wang X, Wang X, Sui X, Gou J, Zhu T, Ma X, Hu W. Preliminarily evaluation the safety and immunogenicity of tetanus, reduced diphtheria and acellular pertussis (five components) combined vaccine, adsorbed (Tdcp) in participants aged 6 years and above: a blinded and randomised, and controlled phase I clinical trial. Front Immunol. 2025 Sep 5;16:1616574. doi: 10.3389/fimmu.2025.1616574. eCollection 2025.

Drugs

Indications