drugset / Trial / NCT06061783
Correction of Hypernatremia by Intravenous Hypotonic Solution Compared to Enteral Water
RandomizedParallel-groupOpen-labelTreatment
Summary
Hypernatremia, defined as an elevation of serum sodium \>145 mEq/L, is one of the most common electrolyte disturbances in hospitalized patients and intensive care units. In this study, the investigator aims, for the first time, to compare two strategies used for the correction of hypernatremia, using intravenous hypotonic solution compared to naso- or orogastric tube enteral water.
Timeline
- Start
- 2023-11-30
- Primary completion
- 2024-09-30
- Completion
- 2024-09-30
Publications
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- Background Sarahian S, Pouria MM, Ing TS, Sam R. Hypervolemic hypernatremia is the most common type of hypernatremia in the intensive care unit. Int Urol Nephrol. 2015 Nov;47(11):1817-21. doi: 10.1007/s11255-015-1103-0. Epub 2015 Sep 16.
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- Background Ma F, Bai M, Li Y, Yu Y, Liu Y, Zhou M, Li L, Jing R, Zhao L, He L, Li R, Huang C, Wang H, Sun S. Continuous Venovenous Hemofiltration (CVVH) Versus Conventional Treatment for Acute Severe Hypernatremia in Critically Ill Patients: A Retrospective Study. Shock. 2015 Nov;44(5):445-51. doi: 10.1097/SHK.0000000000000443.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Glucose | Unknown | 500 ml | Intravenous |
| Comparator | Glucose | Unknown | 1200 ml | Intravenous |
Indications
No indication recorded.