Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans

Phase 1 Completed 122 enrolled University of Zurich

RandomizedParallel-groupDouble-blindBasic science

Summary

The study looks into whether administering psychedelic substances that stimulate the serotonin system influences pro-social behavior when compared to administering substances that stimulate the dopamine system in healthy individuals.

Timeline

Start: 2023-10-24
Primary completion: 2025-09-22
Completion: 2025-09-22

Publications

Background Preller KH, Vollenweider FX. Modulation of Social Cognition via Hallucinogens and "Entactogens". Front Psychiatry. 2019 Dec 3;10:881. doi: 10.3389/fpsyt.2019.00881. eCollection 2019.
Background Cruwys T, Haslam SA, Dingle GA, Haslam C, Jetten J. Depression and Social Identity: An Integrative Review. Pers Soc Psychol Rev. 2014 Aug;18(3):215-238. doi: 10.1177/1088868314523839. Epub 2014 Apr 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Methylphenidate	Small molecule	60 mg	Oral
Comparator	Midomafetamine	Unknown	100 mg	Oral
Comparator	Psilocybin	Other / unclassified	15 mg	Oral

Indications

No indication recorded.