Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting

Summary

"Wait \& see" is currently the standard of care of recently diagnosed desmoid tumors (DT). In case of progression or symptomatic disease, medical therapy is nowadays widely used including chemotherapy. Cryoablation has proven to be beneficial for the treatment of large, progressive and symptomatic DT. This randomized phase II trial aims to compare cryoablation versus medical therapy in DT patients progressing after the "wait \& see" period. Moreover, a cross-over design has been anticipated to allow all patients to undergo cryoablation if necessary.

Timeline

Start

2024-03-04

Primary completion

2027-03

Completion

2029-06

Drugs

Indications