CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

Phase 2 Completed 46 enrolled Medical University of South Carolina American Cancer Society, Inc. · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use. The purpose of the present study is to see how well nicotine patches and lozenges help people quit both smoking and vaping, and to determine if higher doses of the medication work best.

Timeline

Start: 2023-12-05
Primary completion: 2024-11-05
Completion: 2024-11-05

Publications

Palmer AM, DeMass R, Rojewski AM, Bagley EM, Carpenter MJ, Smith TT, Toll BA. Augmented Doses of Nicotine Replacement Therapy: Feasibility for Dual Cigarette and E-Cigarette Cessation. Am J Prev Med. 2025 Aug;69(2):107664. doi: 10.1016/j.amepre.2025.107664. Epub 2025 May 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Nicotine	Unknown	4 mg	—
Comparator	Nicotine	Unknown	21 mg	Other
Comparator	Nicotine	Unknown	35 mg	Other
Comparator	Nicotine	Unknown	42 mg	Other

Indications

No indication recorded.