Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation

Summary

The purpose of this study is to establish the safety and effectiveness of pulsed field ablation as a first-line ablation treatment for subjects with persistent atrial fibrillation as compared to subjects who received an initial treatment with anti-arrhythmic drugs.

Timeline

Start

2023-12-28

Primary completion

2026-02-04

Completion

2028-02-04

Publications

• Wazni OM, Chun KRJ, Nair DG, Anic A, Duytschaever M, Chrispin J, Amin A, Ajijola OA, Gibson DN, Mansour M, Piccini JP, Natale A, Badin A, Osca J, Dukes J, Bhalla K, Hussein A, Senn T, Weiner S, Sood N, Dello Russo A, Sadhu A, Meyers J, Trulock K, Tam MTK, DeLurgio DB, Champagne J, Iacopino S, Kwan B, Albrecht EM, McCammon S, Garlitski AC, Sutton BS, Stein KM, Andrade JG; AVANT GUARD Study Investigators. Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation. N Engl J Med. 2026 Apr 25. doi: 10.1056/NEJMoa2600929. Online ahead of print.

Drugs

Indications