drugset / Trial / NCT06107335

Effect of Albumin Versus Routine Care on Hemodynamic Response and Stability in Patients With Preeclampsia Guided by a Non-invasive Hemodynamic Monitoring System During Cesarean Delivery With Spinal Anesthesia

NCT06107335

Phase 4 Not yet recruiting 62 enrolled The University of Texas Health Science Center, Houston
RandomizedParallel-groupOpen-labelPrevention

Summary

The purpose of this study is to compare the effect of albumin versus routine care on hemodynamic response and stability in pre-eclamptic patients during cesarean delivery. The hypothesis is that volume replacement with albumin guided by stroke volume variation (SVV) using a ClearSight-Acumen (CS-A) monitor, before cesarean delivery (CD), improves hemodynamic stability in preeclamptic patients with severe features compared to routine care, under neuraxial anesthesia.

Timeline

Start
2025-07-01
Primary completion
2026-12-01
Completion
2026-12-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Albumin Protein / enzyme biologic 5 %
Subject Albumin Protein / enzyme biologic 500 ml
Comparator Lactated Ringer's Injection Unknown 75 ml

Indications