drugset / Trial / NCT06108076
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
Phase 0
Recruiting
10 enrolled
The University of Texas Health Science Center at San Antonio
National Center for Advancing Translational Sciences (NCATS) · collab
NaSingle-groupOpen-labelTreatment
Summary
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.
Timeline
- Start
- 2024-01-16
- Primary completion
- 2026-07-31
- Completion
- 2026-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketone Monoester | Unknown | 400 mg/kg | Oral |