Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention

Summary

The aim of this study is to test the efficacy of the two long-acting thiazide-like diuretics indapamide and chlorthalidone in reducing urine supersaturation for calcium oxalate and calcium phosphate compared to the short-acting thiazide diuretic hydrochlorothiazide for the prevention of calcium-containing kidney stones.

Timeline

Start

2024-10-01

Primary completion

2027-06-30

Completion

2027-06-30

Publications

• Background Scoglio M, Bargagli M, Rintelen F, Roumet M, Trelle S, Fuster DG. Indapamide or chlorthalidone to reduce urine supersaturation for secondary prevention of kidney stones: protocol for a randomised, double-blind, cross-over trial (INDAPACHLOR). BMJ Open. 2025 Jun 16;15(6):e101594. doi: 10.1136/bmjopen-2025-101594.

Drugs

Indications