drugset / Trial / NCT06129955

Pucotenlimab Combined With Lenvatinib as a Neodjuvant Therapy for Non Clear Cell Renal Cell Carcinoma

NCT06129955

Phase 2 Unknown 47 enrolled Sun Yat-sen University
NaSingle-groupOpen-labelTreatment

Summary

Through the neoadjuvant treatment with a combination of Pucotenlimab and Lenvatinib, it eventually enables the successful and safe implementation of partial nephrectomy in patients with localized renal cancer, who have indications for nephron-sparing surgery but face significant difficulty in kidney preservation (T1b with an endophytic component ≥75% or T2).

Timeline

Start
2023-11-11
Primary completion
2025-12-31
Completion
2025-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Lenvatinib Small molecule
Subject Pucotenlimab Monoclonal antibody

Indications