drugset / Trial / NCT06140095
Studies to Gain Insight How the Drugs PCSK9-inhibitors and Statins Affect Cholesterol and Bile Acid Metabolism
NaSingle-groupOpen-labelBasic science
Summary
Eight healthy male volunteers will be studied in consecutive sessions regarding the acute effect of evolocumab and atorvastatin on cholesterol and bile metabolism.
Timeline
- Start
- 2024-02
- Primary completion
- 2025-12
- Completion
- 2025-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atorvastatin | Small molecule | 40 mg | — |
| Subject | Evolocumab | Monoclonal antibody | 140 mg | Subcutaneous |
Indications
No indication recorded.