Delayed Cold-Stored Platelets -PLTS-1

Phase 2 Active not recruiting 150 enrolled University Health Network, Toronto Canadian Blood Services · collab Kingston Health Sciences Centre · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada. The study is designed to assess the feasibility of a future, definitive RCT to determine the non-inferiority of cold-stored platelets compared to conventional platelets with respect to hemostatic effectiveness (total number of allogeneic blood products transfused within 24 hours after CPB), as well as safety.

Timeline

Start: 2024-06-05
Primary completion: 2026-09
Completion: 2026-12

Publications

Bartoszko J, Peer M, Grewal D, Ansari S, Callum J, Karkouti K. Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients-a randomized multicentre pilot study (PLTS-1). Pilot Feasibility Stud. 2024 Jun 15;10(1):90. doi: 10.1186/s40814-024-01518-z.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Delayed Cold-Stored Buffy Coat Platelets	Unknown	—	Other
Comparator	Room Temperature Buffy Coat Platelets	Unknown	—	Other

Delayed Cold-Stored Platelets -PLTS-1

Summary

Timeline

Publications

Drugs

Indications