drugset / Trial / NCT06160284
Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
Phase 1
Recruiting
12 enrolled
Yale University
National Institute on Drug Abuse (NIDA) · collabYale Biomedical Imaging Institute · collab
NaSingle-groupOpen-labelBasic science
Summary
This study will examine the synaptotrophic effects of psilocybin among medically healthy, detoxified OUD subjects. Eligible OUD participants will undergo pre- and post- psilocybin administration PET scans with the \[11C\]-UCB-J radiotracer while inpatient.
Timeline
- Start
- 2025-05-28
- Primary completion
- 2027-01
- Completion
- 2027-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Psilocybin | Other / unclassified | 20 mg | — |
| Subject | Psilocybin | Other / unclassified | 25 mg | — |