Safety, Tolerability, and Distribution of Laquinimod Eye Drops : The LION Study

Summary

The LION Study is a prospective, single-center phase 1 clinical trial to evaluate the safety, tolerability, and distribution of Laquinimod administered as topical eye drops for two weeks in human participants.

Timeline

Start

2024-05-03

Primary completion

2025-07

Completion

2025-07

Publications

• El Feky D, Akhavanrezayat A, Mobasserian A, Khan H, Elaraby O, Yavari N, Halim MS, Tram Tran AN, Khatri A, Kirimli GU, Tuong Than NT, Vahtola E, Torngren M, Hung JH, Moussa M, DeBoer C, Mruthyunjaya P, Smith S, Or C, Kabeel M, Serag Y, Do DV, Urtti A, Nguyen QD. Safety and Biodistribution of Topical Laquinimod, an Immunomodulator Targeting Aryl Hydrocarbon Receptor: The LION Study. Ophthalmol Sci. 2026 Apr 3;6(6):101186. doi: 10.1016/j.xops.2026.101186. eCollection 2026 Jun.

Drugs

Indications