Field Evaluations of Innovative Tools for Vector-borne Disease Control in Conflict-affected Communities

Phase 3 Completed 2400 enrolled The Mentor Initiative Liverpool School of Tropical Medicine · collab SCJohnson · collab US government · collab University of Maiduguri · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

The aim of this study is to determine the effectiveness of a new spatial repellent (called Mesh) at repelling multiple disease vectors and, reducing clinical malaria rates in temporary shelters and camp settings. The design of the study will be a two-armed cluster randomised trial. By conducting the research in challenging camp settings in the north of Nigeria, the MENTOR Initiative aims to determine whether Mesh can be effective in harsh camp conditions where communities are living in conflict area temporary shelters.

Timeline

Start: 2023-06-05
Primary completion: 2023-12-31
Completion: 2023-12-31

Outcome

Met primary endpoint

paper spatial repellent emanators significantly reduced malaria infection incidence over 6 months of follow-up (incidence rate ratio 0·713, 95% CI 0·584-0·869; p=0·001; PMID 41520670 ↗

Publications

Allan RJ, Scherrer R, Estecha-Querol S, Weetman D, Paris L, Ba'abba Goni U, Idris Abdulhamid F, Nfornuh Alenwi B, Ahmad S, Cross CL, Ashir GM, Waziri M, Ntadom G, Messenger LA. The effectiveness of long-lasting spatial repellent emanators against malaria in humanitarian crisis settings in northern Nigeria: a two-arm pragmatic, open-label, controlled trial. Lancet Infect Dis. 2026 May;26(5):464-474. doi: 10.1016/S1473-3099(25)00684-X. Epub 2026 Jan 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	transfluthrin	Small molecule	2500 mg	Other