drugset / Trial / NCT06183814

A Study of EXG102-031 in Participants With wAMD

NCT06183814 ↗

Phase 1/2 Unknown 42 enrolled Guangzhou Jiayin Biotech Ltd
Non-randomizedSequentialOpen-labelTreatment

Summary

In neovascular (wet) age-related macular degeneration (wAMD), the macula, or the part of the eye that provides the clear, detailed central vision, is being affected by abnormal blood vessel growth and leakage. This leakage affects the vision over time and can lead to severe blurriness or blinding. EXG102-031 was made to block the extra vessel formation which would lead to less leakage affecting the vision. Before EXG102-031 can be tested for its efficacy (if it makes vision better), it must be tested to see if it is safely tolerated to confirm it can continue to be studied in more patients with wAMD.

Timeline

Start
2023-10-12
Primary completion
2025-12-31
Completion
2025-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject EXG102-031 Gene therapy (AAV / viral vector) — Other