drugset / Trial / NCT06185426
Histopathological, Biochemical And Electrophysiological Evaluation Of Single Or Combined Use Of Diode Laser/Steroid Treatment On Facial Nerve Injury
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The objective of the study will be to investigate the effect of low-level diode laser therapy (LLLT) and steroid on facial nerve injury. Thirty five male Wistar rat will randomly be divided into five groups: healthy control (HCG); damage control (DC); laser (LG); steroid (SG); and combined laser and steroid group (LSG). Right facial nerve electromyography (EMG) data will record after facial nerve damage done and before sacrification at 4th week.The results will be evaluated histopathologically, electrophysiologically and biochemically.
Timeline
- Start
- 2021-01-01
- Primary completion
- 2023-06-01
- Completion
- 2024-02-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methylprednisolone | Other / unclassified | 1 mg/kg | Other |
| Background | Methyprednisolon and low level laser theraphy | Unknown | 50 mg/kg | Other |
| Background | Xylazine | Small molecule | 10 mg/kg | Other |