Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk

Summary

This study will investigate whether a single dose of diazepam (5mg) compared to placebo can modulate brain chemistry (GABA/glutamate levels) and function (blood flow, neural response and connectivity during tasks and at-rest) in 24 individuals at clinical high-risk for psychosis.

Timeline

Start

2019-07-24

Primary completion

2023-03-24

Completion

2023-03-24

Publications

• Kiemes A, Livingston NR, Lukow PB, Knight S, Jelen L, Reilly T, Dima A, Nettis MA, Lythgoe DJ, Casetta C, Egerton A, Spencer T, De Micheli A, Fusar-Poli P, Grace AA, Williams SCR, McGuire P, Davies C, Stone JM, Modinos G. Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis. Int J Neuropsychopharmacol. 2026 Feb 2;29(2):pyaf078. doi: 10.1093/ijnp/pyaf078.

Drugs

Indications