Impact of Therapy Using Colesevelam Treatment Reducing Bile Acids in Patients With Fontan Circulation.

Summary

This is the first pilot study proposing a novel therapeutic option treating patients with Fontan circulation (FC), a high-risk condition that has no definite treatment options available, other than heart or heart-liver transplantation. The investigator's identification of elevated BA and their association with adverse clinical - investigational features in Fontan patients are novel.

Timeline

Start

2024-06-01

Primary completion

2025-11-01

Completion

2026-05-01

Publications

• Shah AH, Armstrong HK, Mittal I, Reimer A, Kunutsor SK, Ducas RA, Alizadeh K, Tam JW, Ravandi A, Dhingra S. IMpact of therapY using coleSevelam treatment reducing bile acids in patients with fonTan cIrCulation (MYSTIC): Rationale and study design. Am Heart J. 2026 Jan;291:81-88. doi: 10.1016/j.ahj.2025.08.011. Epub 2025 Aug 19.

Drugs

Indications