drugset / Trial / NCT06199076

Experimental Study on Alcohol Use and Behavior in Young Adults

NCT06199076 ↗

Phase 2 Terminated 206 enrolled Karolinska Institutet
RandomizedCrossoverTriple-blindTreatment

Summary

The goal of this double blind randomized placebo-controlled clinical trial is to compare intranasal oxytocin and placebo in young adult individuals with alcohol use disorder as compared to healthy controls. The main questions it aims to answer are: * The effect of oxytocin versus placebo on prosocial behavior in individuals with high- versus low alcohol use * The effect of oxytocin versus placebo on impulsivity, emotion recognition, social learning, and alcohol craving in individuals with high- versus low alcohol use Participants in both groups will on two separate visits perform the following validated behavioral task measures: * Dictator game tasks assessing prosocial behavior * Delay discounting task assessing impulsivity * Emotion recognition task assessing emotion recognition * Alcohol cue craving task assessing alcohol craving * Observational fear learning task assessing social learning Researchers will compare groups of high and low alcohol use to see if there is a difference in effect of oxytocin versus placebo between groups.

Timeline

Start
2023-10-17
Primary completion
2025-04-23
Completion
2025-04-23

Outcome

Outcome not reported

Stopped (Enrollment): “Halted due to recruitment problems.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Oxytocin Peptide 24 iu Intranasal