drugset / Trial / NCT06201247

Off-the-shelf CD123 CAR-NK for R/R AML

NCT06201247 ↗

Phase 0 Recruiting 12 enrolled Peking University People's Hospital
NaSingle-groupOpen-labelTreatment

Summary

This is a single-centre, single-arm, open-label, first-in-human (FIH) study to evaluate the safety, tolerability and preliminary efficacy of universal Off-the-shelf CAR-NK cells targeted CD123 (JD123 injection) in the treatment of refractory or relapsed CD123-positive acute myeloid leukemia (AML).

Timeline

Start
2023-12-30
Primary completion
2025-12-30
Completion
2025-12-30

Drugs

EvaluationDrugModalityDoseRoute
Subject JD123 Cell therapy 5e+08 cells —
Subject JD123 Cell therapy 1.5e+09 cells —
Subject JD123 Cell therapy 3e+09 cells —