drugset / Trial / NCT06201247
Off-the-shelf CD123 CAR-NK for R/R AML
NaSingle-groupOpen-labelTreatment
Summary
This is a single-centre, single-arm, open-label, first-in-human (FIH) study to evaluate the safety, tolerability and preliminary efficacy of universal Off-the-shelf CAR-NK cells targeted CD123 (JD123 injection) in the treatment of refractory or relapsed CD123-positive acute myeloid leukemia (AML).
Timeline
- Start
- 2023-12-30
- Primary completion
- 2025-12-30
- Completion
- 2025-12-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | JD123 | Cell therapy | 5e+08 cells | — |
| Subject | JD123 | Cell therapy | 1.5e+09 cells | — |
| Subject | JD123 | Cell therapy | 3e+09 cells | — |